Theis T, Truong ML, Coffey AM, Shchepin RV, Waddell KW, Shi F, Goodson BM, Warren WS, Chekmenev EY. Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization. Journal of the American Chemical Society 2015, 137 (4), 1404-1407.
Shchepin RV, Truong ML, Theis T, Coffey AM, Shi F, Waddell KW, Warren WS, Goodson BM, Chekmenev EY. Hyperpolarization of “Neat” Liquids by NMR Signal Amplification by Reversible Exchange. The Journal of Physical Chemistry Letters 2015, 6 (10), 1961-1967.
Nikolaou P, Coffey AM, Walkup LL, Gust BM, LaPierre CD, Koehnemann E, Barlow MJ, Rosen MS, Goodson BM, Chekmenev EY. A 3D-Printed High Power Nuclear Spin Polarizer. Journal of the American Chemical Society 2014, 136 (4), 1636-1642.
Kovtunov KV, Truong ML, Barskiy DL, Salnikov OG, Bukhtiyarov VI, Coffey AM, Waddell KW, Koptyug IV, Chekmenev EY. Propane-d6 Heterogeneously Hyperpolarized by Parahydrogen. Journal of Physical Chemistry C 2014, 118 (48), 28234–28243.
Barskiy DA, Kovtunov KV, Koptyug IV, He P, Groome KA, Best QA, Shi F, Goodson BM, Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T). Journal of the American Chemical Society 2014, 136 (9), 3322-3325.
Our primary research interests involve the development of hyperpolarized MR technologies for Biomedical use in the following areas: (i) Parahydrogen Induced Polarization contrast agent, catalysis and instrumentation development, (ii) SABRE catalysis, hyperpolarization techniques’ and instrumentation development, (iii) Spin Exchange Optical Pumping (SEOP) clinical-scale hyperpolarizers’ development, (iv) Xenon-Induced Polarization, where the hyperpolarized pool of 129Xe can be used for secondary polarization transfer to 13C-enriched compounds, (v) super-sensitive hyperpolarized low-field MRI. We are working on a wide range of molecular compounds, instrumentation and imaging technologies to apply them to screening and monitoring response to therapy of breast cancer and other diseases. I am grateful to have the help of my current collaborators with on-going projects in the field of hyperpolarized MR including Prof. Boyd Goodson (Southern Illinois University), Samuel Patz (Brigham and Women’s Hospital, Matt Rosen (Harvard University), Mike Barlow (University of Nottingham), Igor Koptyug (International Tomography Center, RAS), Kevin Waddell (Vanderbilt University), Wellington Pham (Vanderbilt University) and Warren Warren (Duke University).