Publications

Truong ML, Theis T, Coffey AM, Shchepin RV, Waddell KW, Shi F, Goodson BM, Warren WS, Chekmenev EY. 15N Hyperpolarization By Reversible Exchange Using SABRE-SHEATH. The Journal of Physical Chemistry C 2015, 119 (16), 8786–8797.

Theis T, Truong ML, Coffey AM, Shchepin RV, Waddell KW, Shi F, Goodson BM, Warren WS, Chekmenev EY. Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization. Journal of the American Chemical Society 2015, 137 (4), 1404-1407.

Shi F, Coffey AM, Waddell KW, Chekmenev EY, Goodson BM. Nanoscale Catalysts for NMR Signal Enhancement by Reversible Exchange. Journal of Physical Chemistry C 2015, 119 (13), 7525–7533.

Shchepin RV, Truong ML, Theis T, Coffey AM, Shi F, Waddell KW, Warren WS, Goodson BM, Chekmenev EY. Hyperpolarization of “Neat” Liquids by NMR Signal Amplification by Reversible Exchange. The Journal of Physical Chemistry Letters 2015, 6 (10), 1961-1967.

Nikolaou P, Goodson BM, Chekmenev EY. NMR Hyperpolarization Techniques for Biomedicine. Chemistry - A European Journal 2015, 21 (8), 3156-3166.

Miller CO, Cao J, Chekmenev EY, Damon BM, Cherrington AD, Gore JC. Noninvasive Measurements of Glycogen in Perfused Mouse Livers Using Chemical Exchange Saturation Transfer NMR and Comparison to 13C NMR Spectroscopy. Analytical Chemistry 2015, 87 (11), 5824-5830.

McClure R, Yanagisawa D, Stec D, Abdollahian D, Koktysh D, Xhillari D, Jaeger R, Stanwood G, Chekmenev EY, Tooyama I, Gore JC, Pham W. Inhalable Curcumin: Offering the Potential for Translation to Imaging and Treatment of Alzheimer's Disease. Journal of Alzheimers Disease 2015, 44 (1), 283-295.

Zu Z, Xu J, Li H, Chekmenev EY, Quarles CC, Does MD, Gore JC, Gochberg DF. Imaging amide proton transfer and nuclear overhauser enhancement using chemical exchange rotation transfer (CERT). Magnetic Resonance in Medicine 2014, 72 (2), 471-476.

Truong ML, Shi F, He P, Yuan B, Plunkett KN, Coffey AM, Shchepin RV, Barskiy DA, Kovtunov KV, Koptyug IV, Waddell KW, Goodson BM, Chekmenev EY. Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Re-versible Exchange. Journal of Physical Chemistry B 2014, 18 (48), 13882–13889.

Truong ML, Harrington MG, Schepkin VD, Chekmenev EY. Sodium 3D COncentration MApping (COMA 3D) using 23Na and proton MRI. Journal of Magnetic Resonance 2014, 247 (0), 88-95.

Truong ML, Coffey AM, Shchepin RV, Waddell KW, Chekmenev EY. Sub-second Proton Imaging of 13C Hyperpolarized Contrast Agents in Water. Contrast Media Mol. Imaging 2014, 9 (5), 333–341.

Theis T, Truong M, Coffey AM, Chekmenev EY, Warren WS. LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization. Journal of Magnetic Resonance 2014, 248, 23-26.

Shi F, Coffey AM, Waddell KW, Chekmenev EY, Goodson BM. Heterogeneous Solution NMR Signal Amplification by Reversible Exchange. Angewandte Chemie International Edition 2014, 53 (29), 7495–7498.

Shchepin RV, Pham W, Chekmenev EY. Dephosphorylation and biodistribution of 1-13C-phospholactate in vivo. Journal of Labelled Compounds and Radiopharmaceuticals 2014, 57 (8), 517-524.

Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. Parahydrogen Induced Polarization of 1-13C-Phospholactate-d2 for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water. Analytical Chemistry 2014, 86 (12), 5601–5605.

Shchepin RV, Chekmenev EY. Toward hyperpolarized molecular imaging of HIV: synthesis and longitudinal relaxation properties of 15N-Azidothymidine. Journal of Labelled Compounds and Radiopharmaceuticals 2014, 57, 621–624.

Perrin BS, Tian Y, Fu RQ, Grant CV, Chekmenev EY, Wieczorek WE, Dao AE, Hayden RM, Burzynski CM, Venable RM, Sharma M, Opella SJ, Pastor RW, Cotten ML. High-Resolution Structures and Orientations of Antimicrobial Peptides Piscidin 1 and Piscidin 3 in Fluid Bilayers Reveal Tilting, Kinking, and Bilayer Immersion. Journal of the American Chemical Society 2014, 136 (9), 3491-3504.

Nikolaou P, Coffey AM, Walkup LL, Gust BM, Whiting NR, Newton H, Muradyan I, Dabaghyan M, Ranta K, Moroz G, Patz S, Rosen MS, Barlow MJ, Chekmenev EY, Goodson BM. XeNA: An automated 'open-source' 129Xe hyperpolarizer for clinical use. Magn. Reson. Imaging 2014, 32 (5), 541-550.

Nikolaou P, Coffey AM, Walkup LL, Gust BM, LaPierre CD, Koehnemann E, Barlow MJ, Rosen MS, Goodson BM, Chekmenev EY. A 3D-Printed High Power Nuclear Spin Polarizer. Journal of the American Chemical Society 2014, 136 (4), 1636-1642.

Nikolaou P, Coffey AM, Ranta K, Walkup LL, Gust B, Barlow MJ, Rosen MS, Goodson BM, Chekmenev EY. Multi-Dimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers. Journal of Physical Chemistry B 2014, 118 (18), 4809–4816.

Nikolaou P, Coffey AM, Barlow MJ, Rosen M, Goodson BM, Chekmenev EY. Temperature-Ramped 129Xe Spin Exchange Optical Pumping. Analytical Chemistry 2014, 86 (16), 8206–8212.

Kovtunov KV, Truong ML, Barskiy DL, Salnikov OG, Bukhtiyarov VI, Coffey AM, Waddell KW, Koptyug IV, Chekmenev EY. Propane-d6 Heterogeneously Hyperpolarized by Parahydrogen. Journal of Physical Chemistry C 2014, 118 (48), 28234–28243.

Kovtunov KV, Truong ML, Barskiy DA, Koptyug IV, Waddell KW, Chekmenev EY. Long-lived Spin States for Low-field Hyperpolarized Gas MRI. Chemistry - A European Journal 2014, 20 (45), 14629 – 14632.

Kovtunov KV, Barskiy DA, Coffey AM, Truong ML, Salnikov OG, Khudorozhkov AK, Inozemtseva EA, Prosvirin IP, Bukhtiyarov VI, Waddell KW, Chekmenev EY, Koptyug IV. High-Resolution 3D Proton MRI of Hyperpolarized Gas Enabled by Parahydrogen and Rh/TiO2 Heterogeneous Catalyst. Chemistry – A European Journal 2014, 20 (37), 11597-11597.

Kovtunov KV, Barskiy DA, Coffey AM, Truong ML, Salnikov OG, Khudorozhkov AK, Inozemceva EA, Prosvirin IP, Bukhtiyarov VI, Waddell KW, Chekmenev EY, Koptyug IV. High-resolution 3D Proton Hyperpolarized Gas MRI Enabled by Parahydrogen and Rh/TiO2 Heterogeneous Catalyst. Chemistry - A European Journal 2014, 20 (37), 11636 – 11639.

Kovtunov KV, Barskiy D, Shchepin RV, Coffey AM, Waddell KW, Koptyug IV, Chekmenev EY. Demonstration of Heterogeneous Parahydrogen Induced Polarization Using Hyperpolarized Agent Migration from Dissolved Rh(I) Complex to Gas Phase. Analytical Chemistry 2014, 86 (13), 6192–6196.

Coffey AM, Kovtunov KV, Barskiy D, Koptyug IV, Shchepin RV, Waddell KW, He P, Groome KA, Best QA, Shi F, Goodson BM, Chekmenev EY. High-resolution Low-field Molecular MR Imaging of Hyperpolarized Liquids. Analytical Chemistry 2014, 86 (18), 9042–9049.

Barskiy DA, Kovtunov KV, Koptyug IV, He P, Groome KA, Best QA, Shi F, Goodson BM, Shchepin RV, Truong ML, Coffey AM, Waddell KW, Chekmenev EY. In Situ and Ex Situ Low-Field NMR Spectroscopy and MRI Endowed by Signal Amplification by Reversible Exchange Hyperpolarization. ChemPhysChem 2014, 15 (18), 4100-4107.

Barskiy DA, Kovtunov KV, Koptyug IV, He P, Groome KA, Best QA, Shi F, Goodson BM, Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T). Journal of the American Chemical Society 2014, 136 (9), 3322-3325.

Shchepin RV, Chekmenev EY. Synthetic approach for unsaturated precursors for parahydrogen induced polarization of choline and its analogs. Journal of Labelled Compounds & Radiopharmaceuticals 2013, 56 (13), 655-662.

Nikolaou P, Coffey AM, Walkup LL, Gust BM, Whiting N, Newton H, Barcus S, Muradyan I, Dabaghyan M, Moroz GD, Rosen MS, Patz S, Barlow MJ, Chekmenev EY, Goodson BM. Near-unity nuclear polarization with an open-source Xe-129 hyperpolarizer for NMR and MRI. Proceedings of the National Academy of Sciences of the United States of America 2013, 110 (35), 14150-14155.

Coffey AM, Truong ML, Chekmenev EY. Low-field MRI can be more sensitive than high-field MRI. Journal of Magnetic Resonance 2013, 237, 169-174.

Cai C, Coffey AM, Shchepin RV, Chekmenev EY, Waddell KW. Efficient Transformation of Parahydrogen Spin Order into Heteronuclear Magnetization. Journal of Physical Chemistry B 2013, 117 (5), 1219-1224.

Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. PASADENA Hyperpolarized C-13 Phospholactate. Journal of the American Chemical Society 2012, 134 (9), 3957-3960.

Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. Parahydrogen-Induced Polarization with a Rh-Based Monodentate Ligand in Water. Journal of Physical Chemistry Letters 2012, 3 (22), 3281-3285.

Feng BB, Coffey AM, Colon RD, Chekmenev EY, Waddell KW. A pulsed injection parahydrogen generator and techniques for quantifying enrichment. Journal of Magnetic Resonance 2012, 214, 258-262.

Coffey AM, Shchepin RV, Wilkens K, Waddell KW, Chekmenev EY. A large volume double channel H-1-X RF probe for hyperpolarized magnetic resonance at 0.0475 T. Journal of Magnetic Resonance 2012, 220, 94-101.

Abramson RG, Arlinghaus LR, Weis J, L iX, Dula AN, Chekmenev EY, Smith S, Miga MI, Abramson V, Yankeelov TE. Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy. Breast Cancer Targets and Therapy 2012, 4, 139-154.

Waddell KW, Coffey AM, Chekmenev EY. In Situ Detection of PHIP at 48 mT: Demonstration Using a Centrally Controlled Polarizer. Journal of the American Chemical Society 2011, 133 (1), 97-101.

Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, Cunningham CH, DeBerardinis RJ, Green GG, Leach MO, Rajan SS, Rizi RR, Ross BD, Warren WS, Malloy CR. Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research. Neoplasia 2011, 13 (2), 81-97.

Harrington MG, Chekmenev EY, Schepkin V, Fonteh AN, Arakaki X. Sodium MRI in a rat migraine model and a NEURON simulation study support a role for sodium in migraine. Cephalalgia 2011, 31 (12), 1254-1265.

Bhattacharya P, Chekmenev EY, Reynolds WF, Wagner S, Zacharias N, Chan HR, Bunger R, Ross BD. Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of C-13 imaging of atheroma in mice. Nmr in Biomedicine 2011, 24 (8), 1023-1028.

Chekmenev EY, Vollmar BS, Cotten M. Can antimicrobial peptides scavenge around a cell in less than a second? Biochimica Et Biophysica Acta-Biomembranes 2010, 1798 (2), 228-234.

Lisitza N, Muradian I, Frederick E, Patz S, Hatabu H, Chekmenev EY. Toward C-13 hyperpolarized biomarkers produced by thermal mixing with hyperpolarized Xe-129. Journal of Chemical Physics 2009, 131 (4), 5.

Hovener JB, Chekmenev EY, Harris KC, Perman WH, Tran TT, Ross BD, Bhattacharya P. Quality assurance of PASADENA hyperpolarization for C-13 biomolecules. Magnetic Resonance Materials in Physics Biology and Medicine 2009, 22 (2), 123-134.

Hovener JB, Chekmenev EY, Harris KC, Perman WH, Robertson LW, Ross BD, Bhattacharya P. PASADENA hyperpolarization of C-13 biomolecules: equipment design and installation. Magnetic Resonance Materials in Physics Biology and Medicine 2009, 22 (2), 111-121.

Chekmenev EY, Norton VA, Weitekamp DP, Bhattacharya P. Hyperpolarized H-1 NMR Employing Low gamma Nucleus for Spin Polarization Storage. Journal of the American Chemical Society 2009, 131 (9), 3164-3165.

Chekmenev EY, Hovener J, Norton VA, Harris K, Batchelder LS, Bhattacharya P, Ross BD, Weitekamp DP. PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy. Journal of the American Chemical Society 2008, 130 (13), 4212-4213.

Chekmenev EY, Chow SK, Tofan D, Weitekamp DP, Ross BD, Bhattacharya P. Fluorine-19 NMR chemical shift probes molecular binding to lipid membranes. Journal of Physical Chemistry B 2008, 112 (20), 6285-6287.

Gor'kov PL, Witter R, Chekmenev EY, Nozirov F, Fu R, Brey WW. Low-E probe for F-19-H-1 NMR of dilute biological solids. Journal of Magnetic Resonance 2007, 189 (2), 182-189.

Gor'kov PL, Chekmenev EY, Li CG, Cotten M, Buffy JJ, Traaseth NJ, Veglia G, Brey WW. Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900 MHz. Journal of Magnetic Resonance 2007, 185 (1), 77-93.

Bhattacharya P, Chekmenev EY, Perman WH, Harris KC, Lin AP, Norton VA, Tan CT, Ross BD, Weitekamp DP. Towards hyperpolarized C-13-succinate imaging of brain cancer. Journal of Magnetic Resonance 2007, 186 (1), 150-155.

Waddell KW, Chekmenev EY, Wittebort RJ. Peptide O-17 chemical shielding and electric field gradient tensors. Journal of Physical Chemistry B 2006, 110 (45), 22935-22941.

Li CG, Mo YM, Hu J, Chekmenev E, Tian CL, Gao FP, Fu RQ, Gor'kov P, Brey W, Cross TA. Analysis of RF heating and sample stability in aligned static solid-state NMR spectroscopy. Journal of Magnetic Resonance 2006, 180 (1), 51-57.

Gor'kov PL, Chekmenev EY, Fu RQ, Hu J, Cross TA, Cotten M, Brey WW. A large volume flat coil probe for oriented membrane proteins. Journal of Magnetic Resonance 2006, 181 (1), 9-20.

Chekmenev EY, Waddell KW, Hu J, Gan ZH, Wittebort RJ, Cross TA. Ion-binding study by O-17 solid-state NMR spectroscopy in the model peptide gly-gly-gly at 19.6 T. Journal of the American Chemical Society 2006, 128 (30), 9849-9855.

Chekmenev EY, Vollmar BS, Forseth KT, Manion MN, Jones SM, Wagner TJ, Endicott RM, Kyriss BP, Homem LM, Pate M, He J, Raines J, Gor'kov PL, Brey WW, Mitchell DJ, Auman AJ, Ellard-Ivey MJ, Blazyk J, Cotten M. Investigating molecular recognition and biological function at interfaces using piscidins, antimicrobial peptides from fish. Biochimica Et Biophysica Acta-Biomembranes 2006, 1758 (9), 1359-1372.

Chekmenev EY, Jones SM, Nikolayeva YN, Vollmar BS, Wagner TJ, Gor'kov PL, Brey WW, Manion MN, Daugherty KC, Cotten M. High-field NMR studies of molecular recognition and structure-function relationships in antimicrobial piscidins at the water-lipid bilayer interface. Journal of the American Chemical Society 2006, 128 (16), 5308-5309.

Chekmenev EY, Gor'kov PL, Cross TA, Alaouie AM, Smirnov AI. Flow-through lipid nanotube arrays for structure-function studies of membrane proteins by solid-state NMR spectroscopy. Biophysical Journal 2006, 91 (8), 3076-3084.

Buffy JJ, Traaseth NJ, Mascioni A, Gor'kov PL, Chekmenev EY, Brey WW, Veglia G. Two-dimensional solid-state NMR reveals two topologies of sarcolipin in oriented lipid bilayers. Biochemistry 2006, 45 (36), 10939-10946.

Waddell KW, Chekmenev EY, Wittebort RJ. Single-crystal studies of peptide prolyl and glycyl N-15 shielding tensors. Journal of the American Chemical Society 2005, 127 (25), 9030-9035.

Hu J, Chekmenev EY, Gan ZH, Gor'kov PL, Saha S, Brey WW, Cross TA. Ion solvation by channel carbonyls characterized by O-17 solid-state NMR at 21 T. Journal of the American Chemical Society 2005, 127 (34), 11922-11923.

Fu R, Brey WW, Shetty K, Gor'kov P, Saha S, Long JR, Grant SC, Chekmenev EY, Hu J, Gan Z, Sharma M, Zhang F, Logan TM, Bruschweller R, Edison A, Blue A, Dixon IR, Markiewicz WD, Cross TA. Ultra-wide bore 900 MHz high-resolution NMR at the National High Magnetic Field Laboratory. Journal of Magnetic Resonance 2005, 177 (1), 1-8.

Chekmenev EY, Hu J, Gor'kov PL, Brey WW, Cross TA, Ruuge A, Smirnov AI. N-15 and P-31 solid-state NMR study of transmembrane domain alignment of M2 protein of influenza A virus in hydrated cylindrical lipid bilayers confined to anodic aluminum oxide nanopores. Journal of Magnetic Resonance 2005, 173 (2), 322-327.

Pometun MS, Chekmenev EY, Wittebort RJ. Quantitative observation of backbone disorder in native elastin. Journal of Biological Chemistry 2004, 279 (9), 7982-7987.

Fan TWM, Lane AN, Chekmenev E, Wittebort RJ, Higashi RM. Synthesis and physico-chemical properties of peptides in soil humic substances. Journal of Peptide Research 2004, 63 (3), 253-264.

Chekmenev EY, Zhang QW, Waddell KW, Mashuta MS, Wittebort RJ. N-15 chemical shielding in glycyl tripeptides: Measurement by solid-state NMR and correlation with x-ray structure. Journal of the American Chemical Society 2004, 126 (1), 379-384.

Zhang QW, Chekmenev EY, Wittebort RJ. O-17 quadrupole coupling and chemical shielding tensors in an H-bonded carboxyl group: alpha-oxalic acid. Journal of the American Chemical Society 2003, 125 (30), 9140-9146.

Chekmenev EY, Xu RZ, Mashuta MS, Wittebort RJ. Glycyl C alpha chemical shielding in tripeptides: Measurement by solid-state NMR and correlation with X-ray structure and theory. Journal of the American Chemical Society 2002, 124 (40), 11894-11899.